Folch university of washington, usa abstract this paper describes a novel microvalve design that can be fabricated using stereolithography. Design and simulation of piezoelectric micropump and microvalve based drug delivery system d. Such pumps are of special interest in microfluidic research, and have become available for industrial product integration in recent. Micro electromechanical systems mems based microfluidic devices have gained popularity in biomedicine field over the last few years. The testing apparatus involved the use of plexiglas. Module iv nanosensors and nanodevices nanosensors and nanodevices for clinical diagnostics nanostructures for drug delivery nano arrays. Micropumps fall under two categories, 1 mechanical micropumps which are characterized by the presence of moving mechanical parts like an oscillating diaphragm or a rotor which exerts pressure on the working fluid for pumping. Design, simulation and study of micropump, microvalve and micro.
Lifting gate pdms microvalves and pumps for microfluidic control. Asee 2014 zone i conference, april 35, 2014, university of bridgeport, bridgpeort, ct, usa. Finally, general discussions on microvalves, micropumps, and micromixers for pcr chips are given. Microvalves and micropumps for biomemsintroduction to. While flow rate is a measure of individual pump performance, it is not a useful metric when comparing pumps of different designs. Aug 21, 2012 the entire scope of the biomems fieldat your fingertipshelping to educate the new generation of engineers and biologists, introduction to biomems explains how certain problems in biology and medicine benefit from and often require the miniaturization of devices. Mems devices pressure sensors, accelerometers, micromotors, micropumps, microvalves, thermal sensors and actuators prosthetics made of mems. Biomems has attracted the attention of many researchers. Apr 08, 2015 active microvalves, including pneumatic, ph change, microfluidic potentiometers, and combinatorial mixers. New materials, understanding of the microenvironment, and biocompatibility. Universityofljubljana facultyofmathematicsandphysics. Microfluidic system concept concept one system to provide all of the possible required analyses for a given type problem all processing steps are performed on the chip no user interaction required except for initialization portable bedside systems possible labonachip body fluid in.
Such a soft material is needed in microvalves and micropumps. The pneumatically actuated pdms microvalve is the most common active. Microvalves and micropumps for biomems open access library. Another form of pinch microvalve is the twist valve developed by weibel et al.
Thus, large deflections and efficient use of pump chamber volume are realized. This represents a highly manual option, but offers advantages in simple, disposable. Additionally, based on their initial mode, microvalves can be divided into normally open, normally closed and. Dow corning was also used in this pump to create molded gaskets. Micro electromechanical systems mems based microfluidic.
Active microvalves, including pneumatic, ph change, microfluidic potentiometers, and combinatorial mixers. Like microvalves, micropumps are essential components to controlling and modulating fluid flow in microfluidic networks. Alternative to pressure driven ow is electroosmosis, where no moving. Although any kind of small pump is often referred to as micropump, a more accurate definition restricts this term to pumps with functional dimensions in the micrometer range. This means micropump products are as close as your local micropump distributor. Discuss the purpose of your concept, and if appropriate, the theory what principles are at work, fabrication materials and techniques. Micropumps microvalves microgrippers springs microspacers micropositioners and from mechanical 2 at dedan kimathi university of technology.
There is a growing trend to fabricate micro drug delivery systems with. Microvalves and micropumps form the foundation of many different microfluidic systems. Polymerbased microfabrication thick photoresist lithography polymeric surface micromachining soft lithography. The race to find effective diagnostic and the therapeutic tools is under way, as biomems are getting closer to the clinical application of intelligent drug delivery devices and significantly enhanced the analytical devices ever before. To solve the flow velocity profile for a fluid that is incompressible, newtonian, isotropic, with viscosity that does not depend on temperature. The performance of a given design varies greatly depending on the particular assembly procedure and there is no standardized performance test against which all microvalves and micropumps can be compared. Finding selectivity coefficient for a mixed ion system. Memsbased micropumps in drug delivery and biomedical applications. The entire scope of the biomems fieldat your fingertipshelping to educate the new generation of engineers and biologists, introduction to biomems explains how certain problems in biology and medicine benefit from and often require the miniaturization of devices. In this paper, a comprehensive overview of microfluidic devices such as micropumps and microneedles has. To solve the flow velocity profile for a fluid that is. Harnessing any phenomenon that accomplishes work at the microscale. Besides hydrodynamic separation, microvalves can sort suspensions of cells or nanoparticles. The early stage of micropump development was for deliverydispensing therapeutic drugs.
Moreover, we printed a 64valve array constructed with 500. Normallyclosed peristaltic micropump with reusable. Micropumps are devices that can control and manipulate small fluid volumes. During the operation of the microvalves and micropumps discussed above, adhesion and friction properties become. Advantageous features of microfluidic devices in biomems. Asee 2014 zone i conference, april 35, 2014, university of. The book covers the whole breadth of this dynamic field, including classical microfabrication. We present the designs with a historical perspective and provide insight into their advantages and. We present the designs with a historical perspective and provide insight into their advantages and limitations for biomedical uses. The performance of a given design varies greatly depending on the particular assembly procedure and there. Peristaltic micropumps are actuated by the sequential deflection of.
Recent trends in mechanical micropumps and their applications. Revolution in drug delivery and analytical techniques. Dec 23, 20 biomems devices must be made of materials that are biocompatible, chemically inert, reliable and useable. Biomems devices are as important to the future of medicine as microprocessors were to the computer revolution at the end of the last century. Biomems have considerable overlap, and is sometimes considered synonymous, with labonachip loc and micro total analysis systems. Micropump products are manufactured with minimal environmental impact enabling earthfriendly pumping innovations.
Design and simulation of piezoelectric micropump and. Two microvalves are used to regulate the microfluid flow inside the pump. Biomems module 6a microvalves and micropumps youtube. Pdf microfluidics has emerged from the memstechnology as an important research field and a promising market. Propose a new biomems device, or expand upon a previously published device or useful methodology. Asee 2014 zone i conference, april 35, 2014, university. Biomems is typically more focused on mechanical parts and microfabrication technologies made suitable for biological applications.
Memsbased micropumps in drug delivery and biomedical applications a. Micropumps microvalves microgrippers springs microspacers. Microvalves control routing, timing, and separation of fluids within a microfluidic device and are crucial for designs with complex functionality. This pdf file below shows how to calculate the youngs modulus and poisson ratio based on the stiffness matrix.
These distributors provide assistance in solving challenging fluid handling applications. Biomems module 6b microvalves and micropumps youtube. Material databases virtual prototyping solid modeling process modeling wet and dry etching of channels automated layout tools for mask generation. Biomems and microsystems video course course outline this course covers topics on introduction to biomems and microfluidics,important materials for fabrication of biomems platforms,design of ise. Micropumps, on the other hand, are responsible for generating. Microvalves and micropumps for biomems semantic scholar. Overall, we demonstrate the 3dprinting of compact microvalves and micropumps using a process that precludes the need for specialized, timeconsuming labor.
Overview micropump products are distributed and supported by trained, qualified independent distributors and representatives. Electrical and mechanical micropumps are largely employed in microfluidic manipulation laser and santiago, 2004. Further, medical conditions like bone infection, cancer, and tumors have employed micropumps for drug delivery into cancerous. Fundamentals of biomems and medical microdevices 2006. Important features, operation mechanisms, and examples of. First, the types of microvalves in pcr chips are discussed, including active and passive microvalves. Jun 07, 2011 micro electromechanical systems mems based microfluidic devices have gained popularity in biomedicine field over the last few years.
Rotary micropumps can be driven using an integrated electromagnetic motor or by the presence of an external electric. Biomems module 7a molecular and particle separations using microfluidics motivation for chemical page 1424. Review memsbased micropumps in drug delivery and biomedical. Sen1 1institute of radio physics and electronics, university of calcutta, kolkata, wb, india abstract in the emerging field of mems microfluidics, micropumps and microvalves are two of the most. Micropumps developed between the years 1978 and 1988 were mainly intended to deliver insulin for maintaining the blood sugar level in diabetic patients. Micropumps can be generally classified into two categoriesactive and passive. A robust, coherent system of categorization is helpful for making sense of the diverse set of devices that have been reported. Modeling and analysis of a microfluidic capillary valve dergipark.
Micropumps, microvalves, and micromixers within pcr. An implantable mems micropump system for drug delivery in. Biomems medical microdevices stevenand micropumps active microvalves, including pneumatic, ph change, microfluidic potentiometers, and combinatorial mixers. Discuss the purpose of your concept, and if appropriate, the theory what principles are at work, fabrication materials and techniques, testing, limitations, and biocompatibility of your device. A microchip for continuousflow, magnetically controlled capture and separation of microparticles yao zhou1, yi wang2, and qiao lin1. Here we demonstrate a 3dprintable microvalve that is transparent, built with a biocompatible resin, and has a simple architecture that can be easily scaled up. The value of the youngs modulus of silicon is often required for engineering designs using microelectromechanical systems mems technology. Biomems biomedical micro electromechanical systems. Biomems is an abbreviation for biomedical or biological microelectromechanical systems.
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